Interferon-gamma (IFNy) in macrophage activation syndrome (MAS) associated with systemic juvenile idiopathic arthritis (sJIA). High levels in patients and a role in a murine mas model
نویسندگان
چکیده
Interferon-gamma (IFNg) in macrophage activation syndrome (MAS) associated with systemic juvenile idiopathic arthritis (sJIA). High levels in patients and a role in a murine mas model Claudia Bracaglia, Ivan Caiello, Kathy De Graaf, Giovanni D’Ario, Florence Guilhot, Walter Ferlin, Lidia Melli, Giusi Prencipe, Sergio Davì, Grant Schulert, Angelo Ravelli, Alexei Grom, Cristina De Min, Fabrizio De Benedetti
منابع مشابه
Macrophage activation syndrome in patients with systemic juvenile idiopathic arthritis treated with tocilizumab
Introduction Macrophage activation syndrome (MAS) is a severe, potentially fatal complication of systemic juvenile idiopathic arthritis (sJIA). Changes in therapies, including biologics, have been associated with the onset of MAS. Interleukin-6 (IL-6) plays a major pathogenic role in sJIA; data in animals suggest that high IL-6 levels contribute to the triggering of MAS [1]. Treatment with the ...
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Macrophage activation syndrome (MAS) is a rare feature of rheumatic disorders in children and adolescence and its presentation as the first symptom of rheumatic disorders is very infrequent. A 9-year-old girl, in whom MAS developed, was admitted to our Hospital in Tehran, Iran. She suffered from high grade fever and rash followed by multiple joint swelling months afterwards. Bone marrow aspira...
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Systemic juvenile idiopathic arthritis (sJIA) and its most significant complication, macrophage activation syndrome (MAS), have traditionally been treated with steroids and non-steroidal anti-inflammatory medications. However, the introduction of biologic medications that inhibit specific cytokines, such interleukins 1 and 6, has changed the treatment paradigm for sJIA patients. In this review,...
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Introduction Macrophage activation syndrome (MAS) is a severe complication of autoimmune diseases. It is more often associated with Systemic Juvenile Idiopathic Arthritis (sJIA). It is difficult to distinguish the MAS from a flare of sJIA, infection or medicinal side effects. The MAS can occur during a flare, an infection, a change in the medication or as a side effect of the treatment administ...
متن کاملHigh levels of interferon-gamma (IFNγ) in macrophage activation syndrome (MAS) and CXCL9 levels as a biomarker for IFNγ production in MAS
Objectives Given the similarities between primary and secondary HLH (sec-HLH), including MAS, we measured levels of IFNg, IFNg-related chemokines (CXCL9, CXCL10, CXLC11), and IL-6 in patients with sec-HLH, and in patients with systemic Juvenile Idiopathic Arthritis (sJIA) with or without MAS at sampling and evaluated their relation to disease activity. In addition, we evaluated the correlation ...
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